PlantImRecepV1, Main, Exploration, bibRecord, 000026

The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.

Identifieur interne : 000026 ( Main/Exploration ); précédent : 000025; suivant : 000027

The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.

Auteurs : Kathrin Thor [Royaume-Uni] ; Shushu Jiang [Royaume-Uni, République populaire de Chine] ; Erwan Michard [États-Unis] ; Jeoffrey George [Royaume-Uni, Suisse] ; Sönke Scherzer [Allemagne] ; Shouguang Huang [Allemagne] ; Julian Dindas [Suisse] ; Paul Derbyshire [Royaume-Uni] ; Nuno Leitão [Royaume-Uni] ; Thomas A. Defalco [Royaume-Uni, Suisse] ; Philipp Köster [Suisse] ; Kerri Hunter [Finlande] ; Sachie Kimura [Finlande, Japon] ; Julien Gronnier [Royaume-Uni, Suisse] ; Lena Stransfeld [Royaume-Uni, Suisse] ; Yasuhiro Kadota [Royaume-Uni, Japon] ; Christoph A. Bücherl [Royaume-Uni, Allemagne] ; Myriam Charpentier [Royaume-Uni] ; Michael Wrzaczek [Finlande] ; Daniel Maclean [Royaume-Uni] ; Giles E D. Oldroyd [Royaume-Uni] ; Frank L H. Menke [Royaume-Uni] ; M Rob G. Roelfsema [Allemagne] ; Rainer Hedrich [Allemagne] ; José Feij [États-Unis] ; Cyril Zipfel [Royaume-Uni, Suisse]

Source :

Nature [ 1476-4687 ] ; 2020.

RBID : pubmed:32846426

Descripteurs français

English descriptors

KwdEn :
- Abscisic Acid (metabolism), Arabidopsis (immunology), Arabidopsis (metabolism), Arabidopsis Proteins (metabolism), Calcium (metabolism), Calcium Channels (metabolism), Pathogen-Associated Molecular Pattern Molecules (immunology), Pathogen-Associated Molecular Pattern Molecules (metabolism), Phosphorylation (MeSH), Plant Immunity (MeSH), Plant Stomata (immunology), Plant Stomata (metabolism), Protein Binding (MeSH), Protein-Serine-Threonine Kinases (metabolism), Signal Transduction (MeSH).
MESH :
- chemical , immunology : Pathogen-Associated Molecular Pattern Molecules.
- chemical , metabolism : Abscisic Acid, Arabidopsis Proteins, Calcium, Calcium Channels, Pathogen-Associated Molecular Pattern Molecules, Protein-Serine-Threonine Kinases.
- immunology : Arabidopsis, Plant Stomata.
- metabolism : Arabidopsis, Plant Stomata.
- Phosphorylation, Plant Immunity, Protein Binding, Signal Transduction.

Abstract

Perception of biotic and abiotic stresses often leads to stomatal closure in plants^1,2. Rapid influx of calcium ions (Ca²⁺) across the plasma membrane has an important role in this response, but the identity of the Ca²⁺ channels involved has remained elusive^3,4. Here we report that the Arabidopsis thaliana Ca²⁺-permeable channel OSCA1.3 controls stomatal closure during immune signalling. OSCA1.3 is rapidly phosphorylated upon perception of pathogen-associated molecular patterns (PAMPs). Biochemical and quantitative phosphoproteomics analyses reveal that the immune receptor-associated cytosolic kinase BIK1 interacts with and phosphorylates the N-terminal cytosolic loop of OSCA1.3 within minutes of treatment with the peptidic PAMP flg22, which is derived from bacterial flagellin. Genetic and electrophysiological data reveal that OSCA1.3 is permeable to Ca²⁺, and that BIK1-mediated phosphorylation on its N terminus increases this channel activity. Notably, OSCA1.3 and its phosphorylation by BIK1 are critical for stomatal closure during immune signalling, and OSCA1.3 does not regulate stomatal closure upon perception of abscisic acid-a plant hormone associated with abiotic stresses. This study thus identifies a plant Ca²⁺ channel and its activation mechanisms underlying stomatal closure during immune signalling, and suggests specificity in Ca²⁺ influx mechanisms in response to different stresses.

DOI: 10.1038/s41586-020-2702-1
PubMed: 32846426

Affiliations:

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Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>RIKEN Center for Sustainable Resource Science, Plant Immunity Research Group, Yokohama, Japan.</nlm:affiliation>
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<author><name sortKey="Wrzaczek, Michael" sort="Wrzaczek, Michael" uniqKey="Wrzaczek M" first="Michael" last="Wrzaczek">Michael Wrzaczek</name>
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<author><name sortKey="Oldroyd, Giles E D" sort="Oldroyd, Giles E D" uniqKey="Oldroyd G" first="Giles E D" last="Oldroyd">Giles E D. Oldroyd</name>
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<author><name sortKey="Roelfsema, M Rob G" sort="Roelfsema, M Rob G" uniqKey="Roelfsema M" first="M Rob G" last="Roelfsema">M Rob G. Roelfsema</name>
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<author><name sortKey="Feij, Jose" sort="Feij, Jose" uniqKey="Feij J" first="José" last="Feij">José Feij</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Zipfel, Cyril" sort="Zipfel, Cyril" uniqKey="Zipfel C" first="Cyril" last="Zipfel">Cyril Zipfel</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<affiliation wicri:level="4"><nlm:affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland. cyril.zipfel@botinst.uzh.ch.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.</title>
<author><name sortKey="Thor, Kathrin" sort="Thor, Kathrin" uniqKey="Thor K" first="Kathrin" last="Thor">Kathrin Thor</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Shushu" sort="Jiang, Shushu" uniqKey="Jiang S" first="Shushu" last="Jiang">Shushu Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Michard, Erwan" sort="Michard, Erwan" uniqKey="Michard E" first="Erwan" last="Michard">Erwan Michard</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Maryland, Department of Cell Biology and Molecular Genetics, College Park, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Maryland, Department of Cell Biology and Molecular Genetics, College Park, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
<settlement type="city">College Park (Maryland)</settlement>
</placeName>
<orgName type="university">Université du Maryland</orgName>
</affiliation>
</author>
<author><name sortKey="George, Jeoffrey" sort="George, Jeoffrey" uniqKey="George J" first="Jeoffrey" last="George">Jeoffrey George</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scherzer, Sonke" sort="Scherzer, Sonke" uniqKey="Scherzer S" first="Sönke" last="Scherzer">Sönke Scherzer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Shouguang" sort="Huang, Shouguang" uniqKey="Huang S" first="Shouguang" last="Huang">Shouguang Huang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dindas, Julian" sort="Dindas, Julian" uniqKey="Dindas J" first="Julian" last="Dindas">Julian Dindas</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Derbyshire, Paul" sort="Derbyshire, Paul" uniqKey="Derbyshire P" first="Paul" last="Derbyshire">Paul Derbyshire</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Leitao, Nuno" sort="Leitao, Nuno" uniqKey="Leitao N" first="Nuno" last="Leitão">Nuno Leitão</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Synthace Ltd, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Synthace Ltd, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Defalco, Thomas A" sort="Defalco, Thomas A" uniqKey="Defalco T" first="Thomas A" last="Defalco">Thomas A. Defalco</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koster, Philipp" sort="Koster, Philipp" uniqKey="Koster P" first="Philipp" last="Köster">Philipp Köster</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunter, Kerri" sort="Hunter, Kerri" uniqKey="Hunter K" first="Kerri" last="Hunter">Kerri Hunter</name>
<affiliation wicri:level="4"><nlm:affiliation>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kimura, Sachie" sort="Kimura, Sachie" uniqKey="Kimura S" first="Sachie" last="Kimura">Sachie Kimura</name>
<affiliation wicri:level="4"><nlm:affiliation>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ritsumeikan Global Innovation Research Organization, Ritsumeikan University, Shiga, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Ritsumeikan Global Innovation Research Organization, Ritsumeikan University, Shiga</wicri:regionArea>
<wicri:noRegion>Shiga</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gronnier, Julien" sort="Gronnier, Julien" uniqKey="Gronnier J" first="Julien" last="Gronnier">Julien Gronnier</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stransfeld, Lena" sort="Stransfeld, Lena" uniqKey="Stransfeld L" first="Lena" last="Stransfeld">Lena Stransfeld</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kadota, Yasuhiro" sort="Kadota, Yasuhiro" uniqKey="Kadota Y" first="Yasuhiro" last="Kadota">Yasuhiro Kadota</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>RIKEN Center for Sustainable Resource Science, Plant Immunity Research Group, Yokohama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>RIKEN Center for Sustainable Resource Science, Plant Immunity Research Group, Yokohama</wicri:regionArea>
<wicri:noRegion>Yokohama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bucherl, Christoph A" sort="Bucherl, Christoph A" uniqKey="Bucherl C" first="Christoph A" last="Bücherl">Christoph A. Bücherl</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Dr. Friedrich Eberth Arzneimittel GmbH, Ursensollen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Friedrich Eberth Arzneimittel GmbH, Ursensollen</wicri:regionArea>
<wicri:noRegion>Ursensollen</wicri:noRegion>
<wicri:noRegion>Ursensollen</wicri:noRegion>
<wicri:noRegion>Ursensollen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Charpentier, Myriam" sort="Charpentier, Myriam" uniqKey="Charpentier M" first="Myriam" last="Charpentier">Myriam Charpentier</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wrzaczek, Michael" sort="Wrzaczek, Michael" uniqKey="Wrzaczek M" first="Michael" last="Wrzaczek">Michael Wrzaczek</name>
<affiliation wicri:level="4"><nlm:affiliation>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maclean, Daniel" sort="Maclean, Daniel" uniqKey="Maclean D" first="Daniel" last="Maclean">Daniel Maclean</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oldroyd, Giles E D" sort="Oldroyd, Giles E D" uniqKey="Oldroyd G" first="Giles E D" last="Oldroyd">Giles E D. Oldroyd</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Sainsbury Laboratory Cambridge University, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sainsbury Laboratory Cambridge University, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Menke, Frank L H" sort="Menke, Frank L H" uniqKey="Menke F" first="Frank L H" last="Menke">Frank L H. Menke</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roelfsema, M Rob G" sort="Roelfsema, M Rob G" uniqKey="Roelfsema M" first="M Rob G" last="Roelfsema">M Rob G. Roelfsema</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hedrich, Rainer" sort="Hedrich, Rainer" uniqKey="Hedrich R" first="Rainer" last="Hedrich">Rainer Hedrich</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feij, Jose" sort="Feij, Jose" uniqKey="Feij J" first="José" last="Feij">José Feij</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Maryland, Department of Cell Biology and Molecular Genetics, College Park, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Maryland, Department of Cell Biology and Molecular Genetics, College Park, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
<settlement type="city">College Park (Maryland)</settlement>
</placeName>
<orgName type="university">Université du Maryland</orgName>
</affiliation>
</author>
<author><name sortKey="Zipfel, Cyril" sort="Zipfel, Cyril" uniqKey="Zipfel C" first="Cyril" last="Zipfel">Cyril Zipfel</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK. cyril.zipfel@botinst.uzh.ch.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland. cyril.zipfel@botinst.uzh.ch.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature</title>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abscisic Acid (metabolism)</term>
<term>Arabidopsis (immunology)</term>
<term>Arabidopsis (metabolism)</term>
<term>Arabidopsis Proteins (metabolism)</term>
<term>Calcium (metabolism)</term>
<term>Calcium Channels (metabolism)</term>
<term>Pathogen-Associated Molecular Pattern Molecules (immunology)</term>
<term>Pathogen-Associated Molecular Pattern Molecules (metabolism)</term>
<term>Phosphorylation (MeSH)</term>
<term>Plant Immunity (MeSH)</term>
<term>Plant Stomata (immunology)</term>
<term>Plant Stomata (metabolism)</term>
<term>Protein Binding (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide abscissique (métabolisme)</term>
<term>Arabidopsis (immunologie)</term>
<term>Arabidopsis (métabolisme)</term>
<term>Calcium (métabolisme)</term>
<term>Canaux calciques (métabolisme)</term>
<term>Immunité des plantes (MeSH)</term>
<term>Liaison aux protéines (MeSH)</term>
<term>Molécules contenant des motifs associés aux pathogènes (immunologie)</term>
<term>Molécules contenant des motifs associés aux pathogènes (métabolisme)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines d'Arabidopsis (métabolisme)</term>
<term>Stomates de plante (immunologie)</term>
<term>Stomates de plante (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Pathogen-Associated Molecular Pattern Molecules</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Abscisic Acid</term>
<term>Arabidopsis Proteins</term>
<term>Calcium</term>
<term>Calcium Channels</term>
<term>Pathogen-Associated Molecular Pattern Molecules</term>
<term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Arabidopsis</term>
<term>Molécules contenant des motifs associés aux pathogènes</term>
<term>Stomates de plante</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arabidopsis</term>
<term>Plant Stomata</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Arabidopsis</term>
<term>Plant Stomata</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide abscissique</term>
<term>Arabidopsis</term>
<term>Calcium</term>
<term>Canaux calciques</term>
<term>Molécules contenant des motifs associés aux pathogènes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines d'Arabidopsis</term>
<term>Stomates de plante</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Phosphorylation</term>
<term>Plant Immunity</term>
<term>Protein Binding</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Immunité des plantes</term>
<term>Liaison aux protéines</term>
<term>Phosphorylation</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Perception of biotic and abiotic stresses often leads to stomatal closure in plants<sup>1,2</sup>
. Rapid influx of calcium ions (Ca<sup>2+</sup>
) across the plasma membrane has an important role in this response, but the identity of the Ca<sup>2+</sup>
 channels involved has remained elusive<sup>3,4</sup>
. Here we report that the Arabidopsis thaliana Ca<sup>2+</sup>
-permeable channel OSCA1.3 controls stomatal closure during immune signalling. OSCA1.3 is rapidly phosphorylated upon perception of pathogen-associated molecular patterns (PAMPs). Biochemical and quantitative phosphoproteomics analyses reveal that the immune receptor-associated cytosolic kinase BIK1 interacts with and phosphorylates the N-terminal cytosolic loop of OSCA1.3 within minutes of treatment with the peptidic PAMP flg22, which is derived from bacterial flagellin. Genetic and electrophysiological data reveal that OSCA1.3 is permeable to Ca<sup>2+</sup>
, and that BIK1-mediated phosphorylation on its N terminus increases this channel activity. Notably, OSCA1.3 and its phosphorylation by BIK1 are critical for stomatal closure during immune signalling, and OSCA1.3 does not regulate stomatal closure upon perception of abscisic acid-a plant hormone associated with abiotic stresses. This study thus identifies a plant Ca<sup>2+</sup>
 channel and its activation mechanisms underlying stomatal closure during immune signalling, and suggests specificity in Ca<sup>2+</sup>
 influx mechanisms in response to different stresses.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32846426</PMID>
<DateCompleted><Year>2020</Year>
<Month>11</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>11</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>585</Volume>
<Issue>7826</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Nature</Title>
<ISOAbbreviation>Nature</ISOAbbreviation>
</Journal>
<ArticleTitle>The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.</ArticleTitle>
<Pagination><MedlinePgn>569-573</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41586-020-2702-1</ELocationID>
<Abstract><AbstractText>Perception of biotic and abiotic stresses often leads to stomatal closure in plants<sup>1,2</sup>
. Rapid influx of calcium ions (Ca<sup>2+</sup>
) across the plasma membrane has an important role in this response, but the identity of the Ca<sup>2+</sup>
 channels involved has remained elusive<sup>3,4</sup>
. Here we report that the Arabidopsis thaliana Ca<sup>2+</sup>
-permeable channel OSCA1.3 controls stomatal closure during immune signalling. OSCA1.3 is rapidly phosphorylated upon perception of pathogen-associated molecular patterns (PAMPs). Biochemical and quantitative phosphoproteomics analyses reveal that the immune receptor-associated cytosolic kinase BIK1 interacts with and phosphorylates the N-terminal cytosolic loop of OSCA1.3 within minutes of treatment with the peptidic PAMP flg22, which is derived from bacterial flagellin. Genetic and electrophysiological data reveal that OSCA1.3 is permeable to Ca<sup>2+</sup>
, and that BIK1-mediated phosphorylation on its N terminus increases this channel activity. Notably, OSCA1.3 and its phosphorylation by BIK1 are critical for stomatal closure during immune signalling, and OSCA1.3 does not regulate stomatal closure upon perception of abscisic acid-a plant hormone associated with abiotic stresses. This study thus identifies a plant Ca<sup>2+</sup>
 channel and its activation mechanisms underlying stomatal closure during immune signalling, and suggests specificity in Ca<sup>2+</sup>
 influx mechanisms in response to different stresses.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thor</LastName>
<ForeName>Kathrin</ForeName>
<Initials>K</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5547-4460</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Shushu</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Michard</LastName>
<ForeName>Erwan</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>University of Maryland, Department of Cell Biology and Molecular Genetics, College Park, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>George</LastName>
<ForeName>Jeoffrey</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-6018-8602</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scherzer</LastName>
<ForeName>Sönke</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-7197-2101</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Shouguang</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-7007-0301</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dindas</LastName>
<ForeName>Julian</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-3078-4865</Identifier>
<AffiliationInfo><Affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Derbyshire</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leitão</LastName>
<ForeName>Nuno</ForeName>
<Initials>N</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-8802-5215</Identifier>
<AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Synthace Ltd, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>DeFalco</LastName>
<ForeName>Thomas A</ForeName>
<Initials>TA</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-2897-1485</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Köster</LastName>
<ForeName>Philipp</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hunter</LastName>
<ForeName>Kerri</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kimura</LastName>
<ForeName>Sachie</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-5736-2123</Identifier>
<AffiliationInfo><Affiliation>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ritsumeikan Global Innovation Research Organization, Ritsumeikan University, Shiga, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gronnier</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-1429-0542</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stransfeld</LastName>
<ForeName>Lena</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kadota</LastName>
<ForeName>Yasuhiro</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4782-1418</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>RIKEN Center for Sustainable Resource Science, Plant Immunity Research Group, Yokohama, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bücherl</LastName>
<ForeName>Christoph A</ForeName>
<Initials>CA</Initials>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dr. Friedrich Eberth Arzneimittel GmbH, Ursensollen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Charpentier</LastName>
<ForeName>Myriam</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-3784-3039</Identifier>
<AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wrzaczek</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5946-9060</Identifier>
<AffiliationInfo><Affiliation>Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>MacLean</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-1032-0887</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oldroyd</LastName>
<ForeName>Giles E D</ForeName>
<Initials>GED</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5245-6355</Identifier>
<AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Sainsbury Laboratory Cambridge University, Cambridge, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Menke</LastName>
<ForeName>Frank L H</ForeName>
<Initials>FLH</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-2490-4824</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roelfsema</LastName>
<ForeName>M Rob G</ForeName>
<Initials>MRG</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hedrich</LastName>
<ForeName>Rainer</ForeName>
<Initials>R</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-3224-1362</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feijó</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-1100-5478</Identifier>
<AffiliationInfo><Affiliation>University of Maryland, Department of Cell Biology and Molecular Genetics, College Park, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zipfel</LastName>
<ForeName>Cyril</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-4935-8583</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK. cyril.zipfel@botinst.uzh.ch.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland. cyril.zipfel@botinst.uzh.ch.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><Acronym>ERC_</Acronym>
<Agency>European Research Council</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>26</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nature</MedlineTA>
<NlmUniqueID>0410462</NlmUniqueID>
<ISSNLinking>0028-0836</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029681">Arabidopsis Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015220">Calcium Channels</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000592922">OSCA1 protein, Arabidopsis</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000069452">Pathogen-Associated Molecular Pattern Molecules</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>72S9A8J5GW</RegistryNumber>
<NameOfSubstance UI="D000040">Abscisic Acid</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="C509522">BIK1 protein, Arabidopsis</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>SY7Q814VUP</RegistryNumber>
<NameOfSubstance UI="D002118">Calcium</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nature. 2020 Sep;585(7826):507-508</RefSource>
<PMID Version="1">32895562</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="ErratumIn"><RefSource>Nature. 2020 Nov 17;:</RefSource>
<PMID Version="1">33199921</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000040" MajorTopicYN="N">Abscisic Acid</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029681" MajorTopicYN="N">Arabidopsis Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002118" MajorTopicYN="N">Calcium</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015220" MajorTopicYN="N">Calcium Channels</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000069452" MajorTopicYN="N">Pathogen-Associated Molecular Pattern Molecules</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057865" MajorTopicYN="Y">Plant Immunity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054046" MajorTopicYN="N">Plant Stomata</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>06</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>11</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
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<ArticleId IdType="doi">10.1038/s41586-020-2702-1</ArticleId>
<ArticleId IdType="pii">10.1038/s41586-020-2702-1</ArticleId>
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</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Finlande</li>
<li>Japon</li>
<li>Royaume-Uni</li>
<li>République populaire de Chine</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bavière</li>
<li>Canton de Zurich</li>
<li>District de Basse-Franconie</li>
<li>Grand Londres</li>
<li>Maryland</li>
<li>Uusimaa</li>
</region>
<settlement><li>College Park (Maryland)</li>
<li>Helsinki</li>
<li>Londres</li>
<li>Wurtzbourg</li>
<li>Zurich</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
<li>Université de Zurich</li>
<li>Université du Maryland</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Thor, Kathrin" sort="Thor, Kathrin" uniqKey="Thor K" first="Kathrin" last="Thor">Kathrin Thor</name>
</noRegion>
<name sortKey="Bucherl, Christoph A" sort="Bucherl, Christoph A" uniqKey="Bucherl C" first="Christoph A" last="Bücherl">Christoph A. Bücherl</name>
<name sortKey="Charpentier, Myriam" sort="Charpentier, Myriam" uniqKey="Charpentier M" first="Myriam" last="Charpentier">Myriam Charpentier</name>
<name sortKey="Defalco, Thomas A" sort="Defalco, Thomas A" uniqKey="Defalco T" first="Thomas A" last="Defalco">Thomas A. Defalco</name>
<name sortKey="Derbyshire, Paul" sort="Derbyshire, Paul" uniqKey="Derbyshire P" first="Paul" last="Derbyshire">Paul Derbyshire</name>
<name sortKey="George, Jeoffrey" sort="George, Jeoffrey" uniqKey="George J" first="Jeoffrey" last="George">Jeoffrey George</name>
<name sortKey="Gronnier, Julien" sort="Gronnier, Julien" uniqKey="Gronnier J" first="Julien" last="Gronnier">Julien Gronnier</name>
<name sortKey="Jiang, Shushu" sort="Jiang, Shushu" uniqKey="Jiang S" first="Shushu" last="Jiang">Shushu Jiang</name>
<name sortKey="Kadota, Yasuhiro" sort="Kadota, Yasuhiro" uniqKey="Kadota Y" first="Yasuhiro" last="Kadota">Yasuhiro Kadota</name>
<name sortKey="Leitao, Nuno" sort="Leitao, Nuno" uniqKey="Leitao N" first="Nuno" last="Leitão">Nuno Leitão</name>
<name sortKey="Leitao, Nuno" sort="Leitao, Nuno" uniqKey="Leitao N" first="Nuno" last="Leitão">Nuno Leitão</name>
<name sortKey="Maclean, Daniel" sort="Maclean, Daniel" uniqKey="Maclean D" first="Daniel" last="Maclean">Daniel Maclean</name>
<name sortKey="Menke, Frank L H" sort="Menke, Frank L H" uniqKey="Menke F" first="Frank L H" last="Menke">Frank L H. Menke</name>
<name sortKey="Oldroyd, Giles E D" sort="Oldroyd, Giles E D" uniqKey="Oldroyd G" first="Giles E D" last="Oldroyd">Giles E D. Oldroyd</name>
<name sortKey="Oldroyd, Giles E D" sort="Oldroyd, Giles E D" uniqKey="Oldroyd G" first="Giles E D" last="Oldroyd">Giles E D. Oldroyd</name>
<name sortKey="Stransfeld, Lena" sort="Stransfeld, Lena" uniqKey="Stransfeld L" first="Lena" last="Stransfeld">Lena Stransfeld</name>
<name sortKey="Zipfel, Cyril" sort="Zipfel, Cyril" uniqKey="Zipfel C" first="Cyril" last="Zipfel">Cyril Zipfel</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Jiang, Shushu" sort="Jiang, Shushu" uniqKey="Jiang S" first="Shushu" last="Jiang">Shushu Jiang</name>
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<country name="États-Unis"><region name="Maryland"><name sortKey="Michard, Erwan" sort="Michard, Erwan" uniqKey="Michard E" first="Erwan" last="Michard">Erwan Michard</name>
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<name sortKey="Feij, Jose" sort="Feij, Jose" uniqKey="Feij J" first="José" last="Feij">José Feij</name>
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<country name="Suisse"><region name="Canton de Zurich"><name sortKey="George, Jeoffrey" sort="George, Jeoffrey" uniqKey="George J" first="Jeoffrey" last="George">Jeoffrey George</name>
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<name sortKey="Defalco, Thomas A" sort="Defalco, Thomas A" uniqKey="Defalco T" first="Thomas A" last="Defalco">Thomas A. Defalco</name>
<name sortKey="Dindas, Julian" sort="Dindas, Julian" uniqKey="Dindas J" first="Julian" last="Dindas">Julian Dindas</name>
<name sortKey="Gronnier, Julien" sort="Gronnier, Julien" uniqKey="Gronnier J" first="Julien" last="Gronnier">Julien Gronnier</name>
<name sortKey="Koster, Philipp" sort="Koster, Philipp" uniqKey="Koster P" first="Philipp" last="Köster">Philipp Köster</name>
<name sortKey="Stransfeld, Lena" sort="Stransfeld, Lena" uniqKey="Stransfeld L" first="Lena" last="Stransfeld">Lena Stransfeld</name>
<name sortKey="Zipfel, Cyril" sort="Zipfel, Cyril" uniqKey="Zipfel C" first="Cyril" last="Zipfel">Cyril Zipfel</name>
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<country name="Allemagne"><region name="Bavière"><name sortKey="Scherzer, Sonke" sort="Scherzer, Sonke" uniqKey="Scherzer S" first="Sönke" last="Scherzer">Sönke Scherzer</name>
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<name sortKey="Bucherl, Christoph A" sort="Bucherl, Christoph A" uniqKey="Bucherl C" first="Christoph A" last="Bücherl">Christoph A. Bücherl</name>
<name sortKey="Hedrich, Rainer" sort="Hedrich, Rainer" uniqKey="Hedrich R" first="Rainer" last="Hedrich">Rainer Hedrich</name>
<name sortKey="Huang, Shouguang" sort="Huang, Shouguang" uniqKey="Huang S" first="Shouguang" last="Huang">Shouguang Huang</name>
<name sortKey="Roelfsema, M Rob G" sort="Roelfsema, M Rob G" uniqKey="Roelfsema M" first="M Rob G" last="Roelfsema">M Rob G. Roelfsema</name>
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<country name="Finlande"><region name="Uusimaa"><name sortKey="Hunter, Kerri" sort="Hunter, Kerri" uniqKey="Hunter K" first="Kerri" last="Hunter">Kerri Hunter</name>
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<name sortKey="Kimura, Sachie" sort="Kimura, Sachie" uniqKey="Kimura S" first="Sachie" last="Kimura">Sachie Kimura</name>
<name sortKey="Wrzaczek, Michael" sort="Wrzaczek, Michael" uniqKey="Wrzaczek M" first="Michael" last="Wrzaczek">Michael Wrzaczek</name>
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<country name="Japon"><noRegion><name sortKey="Kimura, Sachie" sort="Kimura, Sachie" uniqKey="Kimura S" first="Sachie" last="Kimura">Sachie Kimura</name>
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<name sortKey="Kadota, Yasuhiro" sort="Kadota, Yasuhiro" uniqKey="Kadota Y" first="Yasuhiro" last="Kadota">Yasuhiro Kadota</name>
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</affiliations>
</record>

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   |wiki=    Bois
   |area=    PlantImRecepV1
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   |clé=     pubmed:32846426
   |texte=   The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.
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	Serveur d'exploration sur les récepteurs immunitaires végétaux
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les récepteurs immunitaires végétaux

The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.

The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.

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